Appearance of ubiquitin positive inclusions in hippocampal granular cells may imply that the non-motor areas maybe also involved in MND, leading to mental abnormalities.

• 海马颗粒细胞内出现泛素阳性包涵体提示此病同时累及非运动系统，并可能与MND临床上智能或精神异常有关。