Androgen receptor gene has 8 exons, because the exon A is very long,we divided it into 5 fragments. The mutations of the exon A will decrease the transactivation function and the regulation function of the target genes.

• 雄激素受体基因包括8个外显子，因为外显子A较长，一般把它分为5段来扩增，外显子A编码转录活性域，外显子A的突变会导致其增强效用的降低，减弱了其对靶基因表达的调节，大大降低了雄激素受体的效用。