Analysis of the PRNP Met129Val polymorphism was then demonstrated that the Met129Met genotype is associated with an increased susceptibility to kuru and the shortest incubation time.

• 由于库鲁病是致死的，当在当地人群中129密码子位点上的纯合子甲硫氨酸基因型频率过低的时候，库鲁病才会进一步选择侵害其他基因型的人。