An increase in creatinine of up to 50% from baseline or to an absolute concentration of 265 mmol/L ( 3 mg/dL),whichever is lower, is acceptable.

• 肌酐增加超过基础值50%25或绝对值达265mmol/L(3mg/dL)无论哪一种情况损害较小，均可以接受。