Along with Avram Hershko and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

• 他们突破性地发现了人类细胞如何控制某种蛋白质的过程，具体地说，就是人类细胞对无用蛋白质的"废物处理"过程。