After binding to the replication origin, ORC provide a pad for the other initiation factors (such as cdc6, Cdt1, MCM2-7) to conform the pre-replicative complex (pre-RC).

• 当ORC与DNA的复制起始位点特异结合后,形成一个平台,之后cdc6、Cdt1及MCM2-7相继结合到ORC上,形成复制前复合物。