Additionally, P14ARF possesses multiple binding domains to bind to the transcription factor E2F-1 and down-regulates the E2F-l-dependant transcription to prompt cell cycle arrest and induce E2Fl-dependant apoptosis.

• 另外P14ARF可通过多个结合结构域与转录因子E2F-1结合，下调E2F-1的转录活性，促使细胞周期停滞，引发E2F-1依赖性细胞凋亡。