Activation of the renin-angiotensin system leads to increased synthesis of aldosterone in these patients.An excess of aldosterone in heart failure leads to sodium retention and myocardial fibrosis.

• 患者体内肾素-血管紧张素系统的过度激活导致了醛固酮合成增加,过多产生的醛固酮导致水钠潴留,心肌纤维化。