Activation of D_3 receptor could regulate ETB receptor function by upregulation of ETB receptor protein expression. The D_3/ETB receptor interaction may be involved in the pathophysiology of essential hypertension.

• D3受体通过对ETB受体蛋白表达的调节作用,从而调控ETB受体的功能,D3/ETB受体之间的异常调节参与了EH发生的发病机制。