Aberrant GBM HS expression has been obsered in seeral glomerular diseases, such as diabetic nephropathy and membranous glomerulopathy, and a decrease in HS generally is associated with proteinuria.

• 一些肾小球疾病中曾见到异常肾小球基底膜硫酸乙酰肝素表达，如糖尿病性肾病变和膜性肾小球病，HS减少通常与蛋白尿有关。