ATN resulting from toxins usually has diffuse tubular involvement, whereas ATN resulting from ischemia (as in profound hypotension from cardiac failure) has patchy tubular involvement.

• 由毒素引起的肾小管坏死通常弥散性累及肾小管，而由缺血（如心衰引起的严重低血压）引起的肾小管坏死则成片状受累。