APP/SWE gene has no effect on cerebral ischemia induced by photothrombosis during the first 30 min,and protects the brain from cerebral ischemia on 2 d after photothrombosis,and the neuroprotective effect disappears on day 7 after photothrombosis.

• APP/SWE在光化学法所致脑缺血最初30 min对缺血程度没有影响,在缺血后2d可起到神经保护作用,减小梗塞体积,在缺血后7d神经保护作用消失。