APP 5-mer peptide and analog 165 had neurotrophic ef fect on SY5Y cells and could increase the livability of human neuroblastoma cell s SY5Y. The ability of the ananlog 165 to resist pepsin digestion was better tha n that of APP 5-mer peptide.

• APP5肽及类似物165对SY5Y细胞具有神经营养作用,而APP5肽类似物165具有更强的抗胃蛋白酶消化能力。