AML 1 gene abnormalities, including both chromosome translocation and mutation (point mutation, insertion, deletion mutation, et al), which lead to the lost of transcript activation, are general in acute leukemia.

• 在急性白血病中常见AML1基因结构异常，包括平衡易位及突变(如点突变、插入或缺失突变等)，导致AML1的转录活性丧失，提示此基因功能缺失在急性白血病的发生及发展中起着重要作用。