AIM To study toxicokinetics of chiglitazar,a new drug for treating diabetes,and evaluate the relationship between exposure level and dose,exposure level and sex.

• 目的研究治疗糖尿病新药西格列羧长期毒性剂量下,原形药物在比格犬体内的毒代动力学,以评价西格列羧的全身暴露水平,确定暴露水平与给药剂量和性别的相互关系。