A possible role for MMP-2(gelatinase A) and MMP-9(gelatinase B) in acute leukemia has been hypothesized, because of the role of MMP-2 and MMP-9 in tumor.

• 研究发现，许多细胞因子对MMP-2和MMP-9有调节作用，反之亦然。MMP、其天然抑制剂TIMP和微环境中的细胞因子三者之间相互调节，构成一个交叉网络而发挥其功能。