A new kind of bicyclic ortho ester,4-(hydroxymethyl)-2.6,7-trioxabicyclo[2.2.2]octane was synthesized by the reaction between trimthyl orthoformate and pentaerythritol without catalyst.

• 由原甲酸三乙酯与季戊四醇为原料制备了一种双环原酸酯4-羟甲基-2,6,7-三氧杂二环(2,2,2)辛烷,并提供了一条简单可行的合成途径。