A highly conserved C-terminal sequence QVS(A)PA was altered due to P347L and thereby resulting in an aberrant subcellular localization of rhodopsin.

• P34 7L突变改变了 RHO基因 C末端一段高度保守的氨基酸序列 ,致使视紫红质蛋白在细胞内的运输发生障碍。