A 59-year-old man receiving long-term lamivudine therapy experienced a fatal exacerbation of hepatitis B virus (HBV) infection resulting in hepatic necrosis following the emergence of variant HBV.

• 一例长期使用拉米夫定治疗的59岁男性患者在HBV变异株出现后乙肝病毒感染发生致命性加重，导致肝坏死。