6,7-Dihydro-5H-cyclopenteno[b]pyridine, a key intermediate of cefpirome, was synthesized from diethyl adipate by condensation, amination, cyclization, hydrolysis/decarboxylation, chlorination and dechlorination with an overall yield of 31%.

• 己二酸二乙酯经缩合、氨化、闭环、水解后脱羧、氯化及脱氯等6步反应制得头孢匹罗的中间体6,7-二氢-5H-环戊烯并[b]吡啶,总收率31%25。