54-N1 and 69-N2 peptides therefore have potential values in development of nasal spray as new NA inhibitors for broad-spectrum antivirus therapy.

• 54-N1和69-N2作为新的流感病毒神经氨酸酶抑制剂,与现有NA抑制剂Oseltamivir进行了比较和讨论,为进一步研制局部应用的广谱抗流感病毒的鼻腔喷雾剂奠定了基础。