[Conclusions] (1) IL-18 may be as a predict index of advanced DN in 2 type diabetes mellitus (2) IL-18 may play important roles in the pathogenesis and progression of type 2 diabetes mellitus and DN.

• 结论IL-18在2型DM患者中可能成为DN的早期诊断指标; IL-18在2型DM及DN的发生与发展中可能发挥重要的作用。